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Check Closely (three)pentobarbital will decrease the level or outcome of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Powerful or average CYP3A4 inducers might raise amount of diazepam elimination; as a result, efficacy of diazepam may be decreased.pentobarbital will reduce the level or influenc